Synthetic Route of 75476-86-7, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 75476-86-7 as follows.
(a) A solution of 6-bromo-indan-1 -ol (1 mmol) and NEt3 (4 mmol) in dry THF (5 ml_) was stirred at -15 5C under argon. A solution of methanesulfonyl chloride (2 mmol) in dry THF (1 ml_) was cooled to -78 5C and then slowly added to the alcohol solution maintaining the temperature below 0 5C. The reaction mixture was stirred for 2h at -15 5C and then purged with dimethylamine gas (12 mmol). The reaction mixture was allowed to warm to room temperature and stirred overnight. Then, it was filtered to remove salts and solvent was evaporated. Crude was dissolved in CH2CI2 and extracted with HCI 1 M (3x). The aqueous phase was basified withNaOH 6M to pH 8-9 and extracted with CH2CI2. The combined organic extracts were dried over MgS04 and concentrated to dryness. The crude was used in next step without further purification.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,75476-86-7, its application will become more common.
Reference:
Patent; LABORATORIOS DEL DR. ESTEVE, S.A.; GARCIA-LOPEZ, Monica; TORRENS-JOVER, Antoni; ALONSO-XALMA, Monica; WO2011/42343; (2011); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts