The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 3279-95-6, name is 2-(Aminooxy)ethanol. This compound has unique chemical properties. The synthetic route is as follows. Quality Control of 2-(Aminooxy)ethanol
Obtained in Step 3 3,4-difluoro-2- (2-fluoro-4-iodo – phenylamino) -5-vinyl – benzoic acid (180 g, 0.429 mmol) and 3-hydroxy-4-oxo-3 , 4-dihydro-1,2,3-benzotriazine (77.0 g, 0.472 mmol) was dissolved in N, N- dimethylformamide (2 L), 1- (3- dimethylaminopropyl) -3-ethylcarbodiimide hydrochloride salt (87.2 g, 0.455 mol) and the mixture was stirred for 2 hours at room temperature. After confirming the generation and disappearance of the starting material of the active ester in LC-MS, cooling the reaction system to 0 C. The resulting 2-aminooxy in step 5 – ethanol (39.7g, 0.515 mol) and the mixture was stirred for 2 h at 0 C. To confirm the disappearance of the generation and active ester of condensates at the LC-MS. The reaction solution 0.3N hydrochloric acid (2 L) and saturated brine (500 ml) was added and the resulting mixture was extracted with ethyl acetate (2 x 2 L). The organic layers were combined, 0.3N hydrochloric acid (2L), saturated aqueous sodium bicarbonate solution (2 x 2 L), washed with saturated brine (2L), dried over anhydrous sodium sulfate, the objective compound as a white solid concentrated under reduced pressure to 3,4-difluoro-2- (2-fluoro-4-iodo – phenylamino)-N- (2-hydroxy – ethoxy) -5-vinyl – benzamide (179 g, 87%).
With the rapid development of chemical substances, we look forward to future research findings about 3279-95-6.
Reference:
Patent; CHUGAI PHARMACEUTICAL COMPANY LIMITED; UETO, TAKAMITSU; TAKATA, NORIYUKI; (19 pag.)JP2016/34901; (2016); A;,
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