Adding a certain compound to certain chemical reactions, such as: 756520-66-8, 1-(2,6-Dichloro-3-fluorophenyl)ethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 756520-66-8, blongs to alcohols-buliding-blocks compound. Recommanded Product: 1-(2,6-Dichloro-3-fluorophenyl)ethanol
General procedure: 1-(2-chloro-5-fluorophenyl)ethan-1-ol (2.200 g, 12.6 mmol),triphenylphosphine (3.976 g, 15.1 mmol) and 5-bromo-2-nitropyridin-3-ol(2.755 g, 12.6 mmol) was dissolved in anhydrous THF(20 mL) and stirred for 30 minutes in an ice bath. The diisopropylazodiformate (3.057 g, 15.1 mmol) was added to the reaction solutionslowly at 0 oC and the mixture was stirred for4 h at room temperature. Then, the solution was concentrated with a rotaryevaporator. The crude product was purified by silica gelchromatography (petroleum ether/ethyl aceate = 100: 1, v/v) to obtain the titleproduct as white solid (4.232 g, 89.5 %).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,756520-66-8, its application will become more common.
Reference:
Article; Wang, Wanqi; Diao, Yanyan; Li, Wenjie; Luo, Yating; Yang, Tingyuan; Zhao, Yuyu; Qi, TianTian; Xu, Fangling; Ma, Xiangyu; Ge, Huan; Liang, Yingfan; Zhao, Zhenjiang; Liang, Xin; Wang, Rui; Zhu, Lili; Li, Honglin; Xu, Yufang; Bioorganic and Medicinal Chemistry Letters; vol. 29; 12; (2019); p. 1507 – 1513;,
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