In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 149965-40-2, name is (5-Bromo-2-chlorophenyl)methanol, the common compound, a new synthetic route is introduced below. Recommanded Product: (5-Bromo-2-chlorophenyl)methanol
[179.1] (5-Bromo-2-chlorophenyl)methanol (8.187 g) was dissolved in 100 ml of toluene, 12.2 g of diphenylposhorazide and 6.52 ml of diazabicycloundecene were added successively, and the mixture was stirred overnight at room temperature. After ethyl acetate was added thereto, the reaction mixture was successively washed with water and brine, dried over anhydrous magnesium sulfate, and the solvent was removed. The residue was purified by silica gel column, to give 9.75 g of the title compound in the 50:1 hexane-ethyl acetate fraction.1H-NMR(CDCl3) delta: 4.48 (s, 2H) 7.28 (d, J=8.4Hz, 1H) 7.41 (dd, J=2.4, 8.4Hz, 1H) 7.56 (d, J=2.4Hz, 1H)
The synthetic route of 149965-40-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Eisai Co., Ltd.; EP1394147; (2004); A1;,
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