Reference of 24006-92-6, Adding some certain compound to certain chemical reactions, such as: 24006-92-6, name is (4,5-Dichloro-1,2-phenylene)dimethanol,molecular formula is C8H8Cl2O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 24006-92-6.
Into a 100-mL round-bottom flask, was placed a solution of (4,5-dichloro-1,2-phenylene)dimethanol (500 mg, 2.41 mmol, 1.00 equiv) in dichloromethane (50 mL) and tribromophosphane (1.30 g, 4.80 mmol, 2.00 equiv). The resulting solution was stirred overnight at room temperature. The mixture was poured into 50 mL of water/ice. The resulting solution was extracted with 3×100 mL of ethyl acetate, dried over anhydrous sodium sulfate and concentrated under vacuum. The residue was applied onto a silica gel column with ethyl acetate/petroleum ether (1:100). The collected fraction was concentrated under vacuum to give 1,2-bis(bromomethyl)-4,5-dichlorobenzene (400 mg, 50%) as off-white oil. 1H-NMR (CDCl3, 4001411z, ppm): delta 7.48 (s, 2H), 4.57 (s, 4H).
According to the analysis of related databases, 24006-92-6, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Forma Therapeutics, Inc.; Bair, Kenneth W; Barczak, Nicholas; Han, Bingsong; Lancia, JR., David R.; Liu, Cuixian; Martin, Matthew W; Ng, Pui Yee; Rudnitskaya, Aleksandra; Thomason, Jennifer R; Zablocki, Mary Margaret; Zheng, Xiaozhang; (195 pag.)US2016/264518; (2016); A1;,
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