Application of 627-30-5, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 627-30-5, name is 3-Chloropropan-1-ol. This compound has unique chemical properties. The synthetic route is as follows.
2. Preparation of 3-Chloro-1-trimethylsilyloxy-propane Lot 8853 (461-6) A one liter, three-necked flask was fitted with a large magnetic stir bar, a reflux condenser, a teflon clad thermocouple, a 250 ml. pressure-equalizing addition funnel, and an argon inlet. This apparatus was dried in an oven overnight, assembled hot, and allowed to cool to room temperature in a stream of argon. The flask was charged with 189.08 grams (2.00 mole, 1.00 equivalent) of 3-chloro-1-propanol, and 400 ml. of cyclohexane. This formed a two-phase solution. Hexamethyldisilazane, 167.86 grams (1.04 mole, 0.52 equivalent) was then added dropwise. There was an initial exotherm, then the temperature slowly declined. The reaction flask was swept with a slight positive flow of argon, above the level of the liquid. After about one third of the feed had been added, ammonia fumes were detected exiting from the apparatus with pH paper. Total feed time was ninety five minutes. At the end of the feed, the reaction mixture was homogenous. The reaction mixture was stirred at room temperature for two hours, then an aliquot was withdrawn, and analyzed by Gas Chromatography (GC). The conversion to the desired product was 74.6%. The catalyst, trimethylsilylchloride (0.5 ml.) was then added with a pipette. A white precipitate formed immediately. The reaction mixture was heated to reflux with a heating mantle. After two and three quarter hours heating, the heat source was removed. After six and a quarter hours, an aliquot was removed, and analyzed by GC. The conversion to the desired product was 92.0%. The reaction mixture was again heated to reflux, and held at reflux for an additional five hours, then allowed to stir at room temperature overnight. In the morning, the reaction mixture was still hazy. The conversion was 98.4%. The reaction mixture was heated to reflux for an additional three hours, then allowed to cool to room temperature. The reaction mixture was clear and homogenous at this time. The conversion was 98.8%. The total time the reaction mixture was at reflux was ten and three-quarters of an hour. The reaction mixture was transferred to a dry, one liter, single-necked flask. The product was purified by distillation through a twelve inch Vigreux column. The desired product had a boiling point of 154-157 C. This afforded a clear, colorless oil, yield=298.59 grams, 90.2%.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 627-30-5, 3-Chloropropan-1-ol.
Reference:
Patent; FMC Corporation; US5403946; (1995); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts