As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 575-03-1, name is 7-Hydroxy-4-(trifluoromethyl)coumarin, molecular formula is C10H5F3O3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Recommanded Product: 7-Hydroxy-4-(trifluoromethyl)coumarin
Under an argon atmosphere, 4-Trifluoromethylumbelliferone (0.2 g, 0.869 mmol) and pyridineIt was cooled and dissolved in emissions (4.3 mL) ice.Anhydrous trifluoromethanesulfonic acid (0.16 mL, 0.956 mmol) was added dropwise.Then the mixture was stirred at room temperature for 2 hours.After completion of the reaction, and extracted with ethyl acetate, 1 TadashiIt was washed at a constant hydrochloric acid and a saturated saline solution.The organic layer was dried over anhydrous sodium sulfate and the solvent was distilled off.Purification silica gel column (SiOTwo. At 40 g), resulting white solid compound (285 mg, 90percent)
With the rapid development of chemical substances, we look forward to future research findings about 575-03-1.
Reference:
Patent; HIROSAKI UNIVERSITY; PEPTIDE INSTITUTE INCORPORATED; YAMADA, KATSUYA; SASAKI, AYAKO; TESHIMA, TADASHI; YAMAMOTO, TOSHIHIRO; OTSUKA, YUJI; (81 pag.)JP2015/205870; (2015); A;,
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