New downstream synthetic route of

Electric Literature of 2425-41-4, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.2425-41-4, name is (2-Phenyl-1,3-dioxane-5,5-diyl)dimethanol, molecular formula is C12H16O4, molecular weight is 224.25, as common compound, the synthetic route is as follows.

Example 1Compound 204, of which structure was shown above, was synthesized from monobenzalpentaerythritol (Compound A) known from literature [described in Org. Syntheses Coll., Vol. 4, 679 (1963)] as a starting material according to the following scheme. Two hydroxy groups of Compound A were condensed with phytanic acid by using a condensing agent, EDC (l-ethyl-3-(3-dimethylamino)propylcarbodiimide hydrochloride), to obtain a diester compound, Compound B [Jikken Kagaku Koza (Lecture of Experimental Chemistry), 4th edition, edited by the Chemical Society of Japan, Maruzen, Vol. 22, p.258]. The benzylidene group of Compound B was successively removed by catalytic reduction [Hanessian et al, Synthesis, 396 (1981)], and then one of the hydroxy groups was made into an oleic acid ester (Compound C). The other hydroxy group and 8-hydroxyoctanoic acid were condensed to convert the compound into an omega -hydroxy ester compound, Compound D204.

Statistics shows that 2425-41-4 is playing an increasingly important role. we look forward to future research findings about (2-Phenyl-1,3-dioxane-5,5-diyl)dimethanol.

Reference:
Patent; FUJIFILM CORPORATION; WO2007/72983; (2007); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts