Reference of 627-30-5, Adding some certain compound to certain chemical reactions, such as: 627-30-5, name is 3-Chloropropan-1-ol,molecular formula is C3H7ClO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 627-30-5.
MTCOH (8.82 g, 55 mmol) was converted to MTCOCl using standard procedures with oxalyl chloride. In a dry 250 mL round bottom flask equipped with a stir bar, the formed intermediate was dissolved in 150 mL of dry methylene chloride. Under nitrogen flow an addition funnel was attached in which 3-chloropropanol (4.94 g, 4.36 mL, 52.25 mmol), pyridine (3.95 g, 4.04 mL, 55 mmol), and 50 mL of dry methylene chloride was charged. The flask was cooled to 0 C. using an ice bath and the top solution was added drop wise during a period of 30 minutes. The formed solution was stirred for an additional 30 minutes before the ice bath was removed and the solution was stirred for an additional 16 hours under nitrogen. The crude product MTC-PrCl was directly applied onto a silica gel column and the product was separated by eluting with 100% methylene chloride. The product fractions were removed and the solvent was evaporated, yielding the product as off-white oil, which crystallized upon standing. Yield 11 g (85%). 1H-NMR (CDCl3) delta: 4.63 (d, 2H, CH2), 4.32 (t, 2H, CH2), 4.16 (d, 2H, CH2), 3.55 (t, 2H, CH2), 2.09 (m, 2H, CH2), 1.25 (s, 3H, CH3).
According to the analysis of related databases, 627-30-5, the application of this compound in the production field has become more and more popular.
Reference:
Patent; INTERNATIONAL BUSINESS MACHINES CORPORATION; Hedrick, James L.; Lee, Ashlynn L. Z.; Ng, Victor W. L.; Yang, Yi Yan; US2014/301970; (2014); A1;,
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