Adding a certain compound to certain chemical reactions, such as: 307353-32-8, Methyl 3-bromo-5-(hydroxymethyl)benzoate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 307353-32-8, blongs to alcohols-buliding-blocks compound. Application In Synthesis of Methyl 3-bromo-5-(hydroxymethyl)benzoate
Step 1 (0579) Compound iii-51 (300mg, 1.22mmol), (2,4-difluorophenyl)boronic acid (290mg, 1.84mmol), PdCl2 (dppf) (90mg, 0.12mmol) and potassium phosphate (780mg, 3.67mmol) were dissolved into toluene (12mL) under nitrogen atmosphere under microwave irradiation, and the mixture was stirred at 140C for 30 minutes. After the reaction mixture was filtrated by Celite, the solvent was removed in vacuo. The obtained residue was purified by silica gel column chromatography (hexane-ethyl acetate) to give Compound iii-52 (304mg, 89%). 1H-NMR (CDCl3) delta: 8.09-8.05 (m, 2H), 7.72 (d, J = 1.5 Hz, 1H), 7.46-7.40 (m, 1H), 7.00-6.91 (m, 2H), 4.82 (d, J = 5.8 Hz, 2H), 3.94 (s, 3H), 1.83 (t, J = 5.9 Hz, 1H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,307353-32-8, its application will become more common.
Reference:
Patent; Shionogi & Co., Ltd.; KAWASUJI, Takashi; MIKAMIYAMA, Hidenori; SUZUKI, Naoyuki; MASUDA, Koji; SUGIMOTO, Hideki; OKANO, Azusa; YOSHIDA, Miho; SUGIYAMA, Shuichi; ASAHI, Kentarou; KOZONO, Iori; MIYAZAKI, Keisuke; OZASA, Hiroki; MIYAGAWA, Masayoshi; (374 pag.)EP3192794; (2017); A1;,
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