Electric Literature of 149965-40-2, Adding some certain compound to certain chemical reactions, such as: 149965-40-2, name is (5-Bromo-2-chlorophenyl)methanol,molecular formula is C7H6BrClO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 149965-40-2.
A mixture of 5-bromo-2-chlorobenzyl alcohol (2.22 g), tert-butyldimethylsilyl chloride(2.26 g), imidazole (1.36 g) and DMF (25 ml) was stirred at ambient temperature for 1 hour.The mixture was evaporated and the residue was partitioned between ethyl acetate and water.The organic phase was washed in turn with water and with a saturated brine solution, driedover anhydrous sodium sulphate and evaporated. The residue was purified by columnchromatography on silica using an increasingly polar gradient of from 0% to 40% ethyl acetatein isohexane as eluent. There was thus obtained 3-ter^butyldimethylsilyloxymethyl-4-chlorobromobenzene as an oil (2.78 g) which was used without further purification.
According to the analysis of related databases, 149965-40-2, the application of this compound in the production field has become more and more popular.
Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2006/5914; (2006); A1;,
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