Reference of 145691-59-4 ,Some common heterocyclic compound, 145691-59-4, molecular formula is C7H6Br2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
To a stirring cloudy solution of 2.41 g (9.04 mmol) of (3,5-dibromophenyl)methanol in 40 mL of CH2Cl2 at r.t. was added 1.4 mL of Et3N and 62.7 mg of DMAP. The solution was cooled to 0 0C and 1.0 mL of MsCl was added, and the solution was gradually allowed to warm to r.t. After 24.5 h, the organic layer was washed with water (20 mL) and brine (15 mL), dried over Na2SO4, filtered, and concentrated. Purification by flash silica gel chromatography (5% EtOAc/hexanes) provided 1.88 g of l,3-dibromo-5- (chloromethyl)benzene as a yellow oil in 73 % yield and 476 mg of the mesylate (35% EtOAc/hexanes) as a pale yellow solid.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 145691-59-4, (3,5-Dibromophenyl)methanol, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; COMENTIS, INC.; PURDUE RESEARCH FOUNDATION; WO2009/42694; (2009); A1;,
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