Application of 65735-71-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 65735-71-9, name is (4-Chloro-3-(trifluoromethyl)phenyl)methanol, molecular formula is C8H6ClF3O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
(4-Chloro-3-(trifluoromethyl)phenyl)methanol (5.1 g, 24.22 mmol) was added in small portions to SOCl2 (20 mL, 275 mmol). The reaction was stirred at 50 0C for 18 h and then under reflux for 23 h. The mixture was concentrated and dried under high vacuum to give the title compound as a colorless liquid (5.41 g). 1H NMR (400 MHz, CDCl3) delta ppm 4.58 (s, 2H), 7.50- 7.51(1-1, 2H), 7.71 (s, IH).
According to the analysis of related databases, 65735-71-9, the application of this compound in the production field has become more and more popular.
Reference:
Patent; ARENA PHARMACEUTICALS, INC.; JONES, Robert M.; BUZARD, Daniel J.; SCHRADER, Thomas O.; KASEM, Michelle; ZHU, Xiuwen; JOHNSON, Benjamin R.; LEHMANN, Juerg; HAN, Sangdon; KAWASAKI, Andrew M.; WO2011/5295; (2011); A1;,
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