Application of 2077-19-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.2077-19-2, name is 2-(4-Bromophenyl)propan-2-ol, molecular formula is C9H11BrO, molecular weight is 215.09, as common compound, the synthetic route is as follows.
[0168] A mixture of 2-( 4-bromophenyl)propan-2-ol (2.80g, 13.0 mmol), 4,4,4′,4′,5,5,5′,5′-octamethyl-2,2′-bi(1,3,2-dioxaborolane)(3.30 g, 13.0 mmol),AcOK (2.60 g, 26.0mmol)and Pd(dppf)Cl2 (476 mg, 0.65 mmol) in dioxane (60 mL)was stirred at 80 C. for2 hrs underN2 .After HPLC and TLC(PE:Et0Ac=3: 1) showed the reaction was complete, the mixturewas concentrated and purified by MPLC to give the titlecompound (2.00 g, yield: 58.8%) as a white solid.
Statistics shows that 2077-19-2 is playing an increasingly important role. we look forward to future research findings about 2-(4-Bromophenyl)propan-2-ol.
Reference:
Patent; BLUEPRINT MEDICINES CORPORATION; Hodous, Brian L.; (150 pag.)US2016/31892; (2016); A1;,
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