Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 6153-05-5, name is (Z)-3-Methylpent-2-en-4-yn-1-ol. A new synthetic method of this compound is introduced below., Recommanded Product: (Z)-3-Methylpent-2-en-4-yn-1-ol
General procedure: To a stirred solution of (Z)-3-methylpent-2-en-4-yn-1-ol (0.88 g, 9.2 mmol) in dry THF (20 mL)wascooled to 78 °C under an atmosphere of argon. n-Butyl lithium (7.7 mL, 18.4 mmol, 2.4 Min hexane) was then added slowly, via syringe. The mixture was allowed to stir at 78 °C for 1 h,after which, 6-methoxy-2,2-dimethyl-2,3-dihydronaphthalene-1,4-dione 9b (2 g, 9.2 mmol), dissolvedin dry THF (10 mL) was added. The mixture was stirred for a further 1 h at 78 °C, and then thecold bath was removed. The reaction mixture was stirred at r.t. for a further 16 h. The reactionwas quenched by addition of a saturated aqueous solution of NH4Cl. The mixture was stirred for10 min and extracted with ethyl acetate (3 50 mL), washed with water (2 30 mL) and driedover anhydrous Na2SO4. Evaporation of the solvent yielded the desired alcohol as a yellowishoil. The residue was subjected to silica gel chromatography using PE and EtOAc (4:1) as eluentto afford (Z)-(10-hydroxy-30,30-dimethyl-40-oxo-70-methoxy-tetrahydronaphthalene-one-yl)-3-methylpentyl-2-em-4-yn-1-ol 18b (2.37 g, 82percent) as a yellow oil.
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Reference:
Article; Wan, Chuan; Wang, Mingan; Yang, Dongyan; Han, Xiaoqiang; Che, Chuanliang; Ding, Shanshan; Xiao, Yumei; Qin, Zhaohai; Molecules; vol. 22; 12; (2017);,
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