Electric Literature of 75476-86-7, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 75476-86-7 as follows.
A mixture of 15A (11 g, 51.6 mmol) and Ph3P-HBr (17.7 g, 51.6 mmol) in benzene (35 ml_) was heated at 90 9C overnight. After cooling to RT, the solid was filtered and dried in vacuo. The solid was washed with Et2O and acetone, and then vacuum dried to afford 15B (18.9 g, 68%).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,75476-86-7, its application will become more common.
Reference:
Patent; SCHERING CORPORATION; WO2008/100480; (2008); A1;,
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