Analyzing the synthesis route of (4-Bromo-2-methylphenyl)methanol

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,17100-58-2, its application will become more common.

Adding a certain compound to certain chemical reactions, such as: 17100-58-2, (4-Bromo-2-methylphenyl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 17100-58-2, blongs to alcohols-buliding-blocks compound. category: alcohols-buliding-blocks

Step 2 Methanesulfonic acid 4-bromo-2-methyl-benzyl ester; To a solution of (4-bromo-2-methyl-phenyl)-methanol (46.65 g, 0.2320 mol) in DCM (500 mL) at -150C was added mesyl chloride (20.65 mL, 0.2668 mol) followed by TEA (37.04 mL, 0.2668 mol). The reaction was stirred at -150C for 1.5 hour. A saturated solution of NH4Cl was then added at -15 0C and the resulting mixture was extracted with DCM. The EPO organic phase was dried over MgSO4, filtered, and concentrated under reduced pressure to afford methanesulfonic acid 4-bromo-2-metrryl-benzyl ester as a white solid in quantitative yield (65 g), which was used directly in step 3 without further purification

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,17100-58-2, its application will become more common.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; WO2008/55847; (2008); A1;,
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