Electric Literature of 3513-81-3, Adding some certain compound to certain chemical reactions, such as: 3513-81-3, name is 2-Methylenepropane-1,3-diol,molecular formula is C4H8O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 3513-81-3.
2-Methylene-propane-1,3-diol (2.2 g; 24.96 mmol) and dibutyltin oxide (6.85 g; 27.96 mmol) were refluxed in chloroform/methanol (100 ml 10: 1) for 24 h to obtain a clear solution. The solvent was removed under reduced pressure to give the stannoxane derivative as a white solid. Cesium fluoride (7.25 g; 47.7 mmol) was added and the mixture was dried under high vacuum. To this reaction mixture, DMF (20 ml) and benzyl bromide (3.27 ml ; 27.5 mmol) were added and the reaction mixture was stirred for 24 h at 25 °C. After that, the reaction mixture was heated at 50 °C for 1 h. The mixture is cooled to 25 °C and diluted with ethyl acetate (100 ml) and water (2 ml). The reaction mixture is stirred vigorously for 30 min and then filtered through a pad of celite to remove dibutyltin oxide. The filtrate was washed with water and then with brine, dried over Na2SO4 and the solvent was removed under reduced pressure. The crude product was purified by silica gel column chromatography eluting with 20 percent ethyl acetate/hexane to yield 2.6 g (60percent) compound 71a) as oil. 1H-NMR (CDCl3) : delta 7.36-7.28 (m, 5H), 5.20 (s, 1H), 5.15 (s, 1H), 4.51 (s, 2H), 4.19 (s, 2H), 4.10 (s, 2H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 3513-81-3, 2-Methylenepropane-1,3-diol, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; WO2005/92881; (2005); A1;,
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