With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.13826-35-2, name is (3-Phenoxyphenyl)methanol, molecular formula is C13H12O2, molecular weight is 200.23, as common compound, the synthetic route is as follows.Product Details of 13826-35-2
3- (2-hydroxyphenyl) propionic acid methyl (149.8 mg, 0.831 mmol), 3- phenoxybenzyl alcohol (118.2 mg, 0.590 mmol), triphenylphosphine (198.1 mg, 0.755 mmol) in toluene (5 of 5 mL) solution of , DEAD (2M solution in toluene, 374.6muL, 0.749 mmol) was added dropwise at room temperature and stirred for 3 hours at 70 C.. The solvent of the reaction mixture was evaporated, and the residue was purified by column chromatography (hexane: ethyl acetate = 15: 1) to give the title compound (200.2mg, 0.552 mmol, 94%, yellow oil)
At the same time, in my other blogs, there are other synthetic methods of this type of compound,13826-35-2, (3-Phenoxyphenyl)methanol, and friends who are interested can also refer to it.
Reference:
Patent; THE UNIVERSITY OF TOKYO; TOHOKU UNIVERSITY; OHWADA, TOMOHIKO; NAKAMURA, SHO; JUNG, SEJIN; OTANI, YUKO; SAYAMA, MISA; AOKI, JUNKEN; (80 pag.)JP2016/17036; (2016); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts