Reference of 223251-16-9, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 223251-16-9 as follows.
This material is prepared from the amino alcohol 1-[2-(4-Hydroxymethyl-phenoxy)-ethyl]azapine by treatment with thionyl chloride in THF at 0C. Resulting solid is used without further purification.1H-NMR (CDCl3) delta 1.7 (m, 2H), 1.9 (m, 4H), 2.2 (m, 2H), 3.1 (m, 2H), 3.4 (7, 2H), 3.6 (t.2H), 6.9 (d, 2H), 7.3 (d, 2H), 12.5 (1H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,223251-16-9, its application will become more common.
Reference:
Patent; Wyeth; EP1159267; (2004); B1;,
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Alcohols – Chemistry LibreTexts