Reference of 14320-38-8, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.14320-38-8, name is Cyclopent-3-enol, molecular formula is C5H8O, molecular weight is 84.12, as common compound, the synthetic route is as follows.
To a solution of cyclopent-3-en-1-ol (compound 32a, 5.0 g, 59.4 mmol) in THF (100.0 ml) was added NaH (3.1 g, 77.2 mmol) in portions at 0 oC. The reaction was stirred at the same temperature for 30 minutes, then BnBr (10.2 g, 59.4 mmol) was added dropwise. The reaction was warmed to room temperature and stirred for 12 hours. The reaction was quenched with H2O (300 mL) and extracted with EtOAc twice (200 mL). The combined organic layer was dried over Na2SO4, concentrated to give compound 32b (12.5 g, crude) as a brown oil.
Statistics shows that 14320-38-8 is playing an increasingly important role. we look forward to future research findings about Cyclopent-3-enol.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; HU, Taishan; KOU, Buyu; LIN, Xianfeng; LIU, Haixia; ZHANG, Zhisen; (152 pag.)WO2018/11160; (2018); A1;,
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