Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1072-52-2, name is 2-(Aziridin-1-yl)ethanol. A new synthetic method of this compound is introduced below., Quality Control of 2-(Aziridin-1-yl)ethanol
Example 19 (Scheme 14): Preparation of 2-[(2-bromoethyl)-2-[[[2-(beta-D- gulopyranosyloxy)ethyl] amino] carbonyl] -4.6-dinitroanilino] ethyl methanesulfonate(48); Reaction of 37 as in Scheme 14, and chromatography on silica gel, eluting with EtOAc/petroleum ether (2:1) gave a product that was precipitated from a CH2Cl2 solution with i-Pr2O to give 2-[(2-bromoethyl)-2,4-dinitro-6-[[[2,3,4,6-tetra-O-acetyl-beta-D- gulopyranosyl)oxy] ethyl] amino] carbonyl] anilino] ethyl methanesulfonate (47) (2.04 g, 82%) as a yellow solid: mp 70-73 0C; 1H NMR [(CD3)2SO] delta 8.84 (t, / = 5.5 Hz, 1 H), 8.75 (d, / = 2.8 Hz, 1 H), 8.31 (dj = 2.8 Hz, 1 H), 5.27 (d, J = 3.2 Hz, 1 H), 5.17 ‘(ddj = 10.4, 3.5 Hz, 1 H), 4.99 (ddj = 10.3, 8.0 Hz, 1 H), 4.78 (dj = 8.0 Hz, 1 H), 4.28 (tj = 5.4 Hz, 1 H), 4.22 (tj = 6.5 Hz, 1 H), 4.11-3.99 (m, 2 H), 3.94-3.84 (m, 1 H), 3.77-3.68 (m, 1 H), 3.63-3.37 (m, 8 H), 3.13 (s, 3 H), 2.13 (s, 3 H), 2.01 (s, 3 H), 1.97 (s, 3 H), 1.92 (s, 3 H. 13C NMR [(CD3)2SO] delta 169.8, 169.7, 169.4, 169.1, 165.4, 145.8, 145.3, 140.8, 135.8, 127.4, 122.3, 100.1, 70.2, 69.9, 68.5, 67.4, 67.3 (2), 61.2, 54.3, 51.1, 39.4, 36.4, 29.7, 20.4, 20.3, 20.2 (2).
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Reference:
Patent; AUCKLAND UNISERVICES LIMITED; WO2008/30112; (2008); A1;,
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