Related Products of 1208434-90-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1208434-90-5, name is (2,6-Difluoro-3,5-dimethoxyphenyl)methanol, molecular formula is C9H10F2O3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
To a solution of (2,6-difluoro-3,5-dimethoxyphenyl)methanol (1.58 g, 7.74 mmol) in DCM(50 mL) at 0C was added MsC1 (1.76 g, 15.36 mmol,) and TEA (2 equiv). The resulting solutionwas stirred overnight at room temperature and then quenched with water (100 mL). The resulting solution was extracted with DCM and the organic layer was concentrated to afford 1.74 g (80%) of (2,6-difluoro-3 ,5 -dimethoxyphenyl)methyl methanesulfonate as a light yellow solid.
According to the analysis of related databases, 1208434-90-5, the application of this compound in the production field has become more and more popular.
Reference:
Patent; PRINCIPIA BIOPHARMA, INC.; VERNER, Erik; BRAMELD, Kenneth Albert; WO2015/120049; (2015); A1;,
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