Synthetic Route of 217479-60-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 217479-60-2, name is 2,4,6-Trichlorobenzyl alcohol, molecular formula is C7H5Cl3O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Example P9 Preparation of 1,3,5-trichloro-2-chloromethyl-benzene To a stirred solution of 2,4,6-trichlorobenzylalcohol (10.0 g; 47.3 mmol) in chloroform (100 ml) kept under nitrogen atmosphere, thionyl chloride (6.07 ml; 85.1 mmol) was added slowly at 0 C. over a period of 15 minutes followed by catalytic amount of DMF. The reaction mix was allowed to stir at ambient temp for 3 hours. The reaction mixture was quenched with 50 ml of water; the aqueous layer was extracted with DCM (3*100 ml). The combined organic layer was washed with 5% sodium bicarbonate solution (2*50 ml) followed by brine (50 ml) and dried over anhydrous sodium sulphate. The solvent was evaporated under reduced pressure. 10.9 g (100% of theory) of 1,3,5-trichloro-2-chloromethyl-benzene was obtained in form of a white solid. 1H NMR (400 MHz, CHLOROFORM-d) delta ppm 7.37 (s, 2H); 4.82 (s, 2H) MS [M+H]+231/233.
According to the analysis of related databases, 217479-60-2, the application of this compound in the production field has become more and more popular.
Reference:
Patent; SYNGENTA CROP PROTECTION LLC; Stierli, Daniel; Walter, Harald; US2013/72535; (2013); A1;,
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