Adding a certain compound to certain chemical reactions, such as: 637031-88-0, 3,3-Difluorocyclobutanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 637031-88-0, blongs to alcohols-buliding-blocks compound. Product Details of 637031-88-0
To a mixture of A-102 (180 mg, 0.61 mmol), 3,3-difluorocyclobutanol (98.5 mg, 0.91 mmol) and PPh3 (286.81 mg, 1.09 mmol) in THF (3 mL) was added DEAD (190.43 mg, 1.09 mmol) at 0 C. The mixture was allowed to warm and then was stirred at 70 C for 16 hours. After cooling to room temperature, the mixture was concentrated to give the crude product, which was purified by prep-TLC (silica gel, PE: EtOAc = 3:1) and prep-HPLC (Phenomenex Gemini (250 mm x 50 mm, 10 _); A = H20 (0.05% NH4OH) and B = CH3CN; 48-78% B over 8 minutes) to afford Compound 81 (5.08 mg, 0.01 mmol) as a solid. 1H NMR (400MHz, CDC13) _ = 9.57 (d, 1H), 8.34 (s, 1H), 7.93 (d, 2H), 6.97 (d, 2H), 4.83 -4.65 (m, 1H), 3.23 – 3.06 (m, 2H), 2.91 -2.75 (m, 2H). LCMS R, = 1.19 min using Method A, MS ESI calcd. for Ci6H12F5N40 [M+H]+ 371.1, found 371.0.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,637031-88-0, its application will become more common.
Reference:
Patent; PRAXIS PRECISION MEDICINES, INC.; REDDY, Kiran; MARTINEZ BOTELLA, Gabriel; GRIFFIN, Andrew, Mark; MARRON, Brian, Edward; (364 pag.)WO2018/98499; (2018); A1;,
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