Synthetic Route of 112-27-6, Adding some certain compound to certain chemical reactions, such as: 112-27-6, name is 2,2′-(Ethane-1,2-diylbis(oxy))diethanol,molecular formula is C6H14O4, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 112-27-6.
Ag2O (6.9 g, 30 mmol) was added to a solution of triethylene glycol (3.0 g, 20 mmol) in dry CH2Cl2. BnBr (2.6 mL, 22 mmol) was then added dropwise over 5 min, and the mixture was stirred for 2 h. After this time, the suspension was filtered through a pad of Celite, which was thoroughly washed with CH2Cl2. The combined filtrate was concentrated under reduced pressure, and the residue was purified by column chromatography to yield a yellow oil (4.46 g, 92.9%). 1H NMR (300 MHz, CDCl3): delta 7.26-7.35 (m, 5H, Ph), 4.56 (s, 2H, -CH2Ph), 3.73-3.58 (m, 12H, -OCH2CH2O-), 2.80 (br, 1H, -OH); 13C NMR (75 MHz, CDCl3): delta 138.0, 128.2, 127.6, 127.5, 73.1, 72.4, 70.5, 70.4, 70.2, 69.2, 61.5.
According to the analysis of related databases, 112-27-6, the application of this compound in the production field has become more and more popular.
Reference:
Article; Yang, Yang; Xue, Xiao-Chao; Jin, Xiao-Feng; Wang, Li-Jun; Sha, Yin-Lin; Li, Zhong-Jun; Tetrahedron; vol. 68; 35; (2012); p. 7148 – 7154;,
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