Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 23147-58-2, name is Glycerol aldehyde dimer. This compound has unique chemical properties. The synthetic route is as follows. Quality Control of Glycerol aldehyde dimer
A solution of methyl [4-[(3R)-1-(4-aminobutanoyl)-3-piperidinyl]-4-(3′-ethyl-6-fluoro-2-biphenylyl)-4-hydroxybutyl]carbamate (0.027 g, 0.05 mmol) in 2 mL of CH2Cl2 at 25 C. was treated with acetic acid (0.003 mL, 0.05 mmol), glycolaldehyde dimer (3 mg, 0.025 mmol), and sodium triacetoxyborohydride (20 mg, 0.10 mmol) and the mixture was stirred overnight before being quenched with the addition of 0.5 mL of aqueous 2N NaOH and extracted with 10% MeOH/CH2Cl2 (3×2 mL). The combined organic extract was dried (MgSO4), concentrated under reduced pressure, and subjected to reverse phase HPLC to provide methyl [4-(3′-ethyl-6-fluoro-2-biphenylyl)-4-hydroxy-4-((3R)-1-{4-[(2-hydroxyethyl)amino]butanoyl}-3-piperidinyl)butyl]carbamate.
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Reference:
Patent; Baldwin, John J.; Cacatian, Salvacion; Claremon, David; Dillard, Lawrence W.; Flaherty, Patrick T.; Ghavimi-Alagha, Bahman; Ghirlanda, Damiano; Ishchenko, Alexey V.; Kallander, Lara S.; Lawhorn, Brian; Lu, Qing; McGeehan, Gerard; Knapp-Reid, Beth A.; Semus, Simon; Simpson, Robert D.; Singh, Suresh B.; Terrell, Lamont R.; Tice, Colin; Tran, Tritin; Xu, Zherong; Yuan, Jing; Zhao, Wei; Zhao, Yongdong Y.; US2010/317697; (2010); A1;,
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