Related Products of 2425-41-4 ,Some common heterocyclic compound, 2425-41-4, molecular formula is C12H16O4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
The monobenzalpentaerythritol, 12 (4.16 g, 18.5 mmol), (3.4) 12G1-C02H (4a) (20.00 g, 40.75 mmol), and DPTS (5.45 g, 18.5 mmol) were dissolved in anhydrous CH2C12 (100 mL). DCC (9.94 g, 48.2 mmol) dissolved in anhydrous CH2C12 (10 mL) was added and the reaction was stirred for 12 h at room temperature under nitrogen atmosphere. After the reaction was complete, the mixture was diluted, filtered, and rinsed with Et20. The solvent was removed and the crude product was purified by column chromatography (Si02, 10% Et20:hexane) and followed by precipitation in MeOH to give a white solid as a product: 21.18 g (98%). NMR (500 MHz, CDC13) delta 7.60 (m, 2H, 2ArH-6), 7.54 – 7.48 (m, 4Eta, 2ArH-2, PhH- 3, 5), 7.38 (m, 3Eta, 3PhH-2, 4, 6), 6.83 (overlapped d, 2Eta, 2ArH-5), 5.51 (s, 1Eta, CH-acetal), 4.81 (s, 2Eta, ArC02CH2), 4.32 (d, J= 1 1.7 Hz, 2H, 20CHaHb-ring), 4.25 (s, 2H, ArC02CH2), 4.07 – 3.98 (m, 10Eta, 4ArOCH2, 20CHaHb-ring), 1.87 – 1.78 (m, 8Eta, 4ArOCH2CH2), 1.51 – 1.43 (m, 8Eta, 4ArOCH2CH2CH2), 1.26 (m, 64Eta, 4(CH2)8CH3), 0.88 (t, J= 6.8 Hz, 12H, 4G). 13C NMR (126 MHz, CDC13) delta 166.0 (C=0), 165.9 (C=0′), 153.5 (ArC-4), 153.3 (ArC-4′), 148.6 (ArC-3), 148.51 (ArC-3′), 137.6 (PhC-1), 129.1 (PhC-3, 5), 128.3 (PhC-4), 126.1 (PhC-2, 6), 123.5 (ArC- 1), 123.4 (ArC-1 ‘), 122.0 (ArC-6), 121.5 (ArC-6′), H4.3 (ArC-2), 1 14.2 (ArC-2′), 11 1.84 (ArC- 5), 1 11.80 (ArC-5′), 102.2 (CH-acetal), 69.7 (OC-ring), 69.2 (ArOCH2), 69.0 (ArOCH2), 68.9 (ArOCH2′), 63.7 (ArC02CH2), 62.9 (ArC02CH2’), 37.73 (C(CH20)4), 31.8 (CH2CH2CH3), 29.62, 29.60, 29.57, 29.55, 29.52, 29.35, 29.30, 29.28, 29.1, 28.98, 28.96, 25.94 (ArOCH2CH2CH2), 25.88 (ArOCH2CH2CH2), 22.6 (CH2CH3), 14.0 (CH3). The spectroscopic data of 16a are in agreement with those previously reported.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 2425-41-4, (2-Phenyl-1,3-dioxane-5,5-diyl)dimethanol, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; PERCEC, Virgil; WO2014/190024; (2014); A1;,
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