Reference of 4415-82-1, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.4415-82-1, name is Cyclobutylmethanol, molecular formula is C5H10O, molecular weight is 86.13, as common compound, the synthetic route is as follows.
Intermediate D: tert-butyl [(5i?,7S)-8-(cyclobutylmethyl)-l-(3-fluorophenyl)-7-methyl-2-oxo- l,3,8-triazaspiro[4.5]dec-3-en-4-yl]carbamate; To a solution of intermediate C (1.45 g, 3.85 mmol) and cyclobutane carboxaldehyde (0.97 g, 11.6 mmol prepared from alcohol using TPAP/NMO) in DCM (60 mL) at 0 0C was added NaHB(OAc)3 (1.23 g, 5.8 mmol). The mixture was allowed to slowly warm to rt and stir for 18h. The mixture was diluted with aq. NaHCO3 and DCM. The organic layer was isolated, washed sequentially with water and brine, dried with Na2SO4 and concentrated to dryness to give 2.6 g of crude material. Purification using automated SiO2 chromatography (MeOH/DCM) provided 1.5 g of desired tert-butyl [(5i?,7iS)-8-(cyclobutylmethyl)-l-(3-fluorophenyl)-7-methyl- 2-oxo-l,3,8-triazaspiro[4.5]dec-3-en-4-yl]carbamate as a white foam. LCMS (M+H) = 445.
Statistics shows that 4415-82-1 is playing an increasingly important role. we look forward to future research findings about Cyclobutylmethanol.
Reference:
Patent; MERCK & CO., INC.; WO2008/54698; (2008); A2;,
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