Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 355-80-6, name is 2,2,3,3,4,4,5,5-Octafluoro-1-pentanol. A new synthetic method of this compound is introduced below., Safety of 2,2,3,3,4,4,5,5-Octafluoro-1-pentanol
Example 32 Preparation of 2,2,3,3,4,4,5,5-octafluoropentyl bis(pentafluoroethyl-) phosphinate, (C2F5)2P(O)OCH2CF2CF2CF2CF2H Potassium fluoride (0.185 g; 3.2 mmol) is suspended in cooled (0 C.) tris-(pentafluoroethyl)phosphine oxide, (C2F5)3P=O, (9.957 g; 24.6 mmol) in a 100 ml glass flask, and 2,2,3,3,4,4,5,5-octafluoropentan-1-ol (5.491 g; 23.7 mmol) is added dropwise. The reaction suspension is warmed and stirred at room temperature for 46.5 h. After condensation in vacuo (10-3 mbar) at room temperature to 60 C. and double fractional distillation in vacuo (6.10-3 mbar) (b.p.: 31 to 32 C.), 2,2,3,3,4,4,5,5-octafluoropentyl bis-(pentafluoroethyl)phosphinate, (C2F5)2P(O)OCH2CF2CF2CF2CF2H, can be isolated as clear and colourless liquid (1.603 g; 3.1 mmol) in a yield of 13% and a purity of 98%. The isolated product is characterised by means of 1H, 19F and 31P NMR spectra in CD3CN. 1H NMR: delta in ppm: 6.44 t, t (1H), 2JH,F=51.1 Hz, 3JH,F=5.3 Hz; 5.11 t, d (2H), 3JH,F=12.9 Hz, 3JH,P=8.0 Hz. 19F NMR: delta in ppm: -81.3 m (6F); -121.7 m (2F); -123.8 m (4F); -125.5 m (2F); -130.7 m (2F); -139.4 d,m (2F), 2JH,F=51.1 Hz. 31P NMR: delta in ppm: 10.6 quin, m, 2JF,P=92.2 Hz.
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Reference:
Patent; MERCK PATENT GmbH; Ignatyev, Nikolai Mykola; Schulte, Michael; Jablonka, Christoph Alexander; Koppe, Karsten; Frank, Walter; US2015/45572; (2015); A1;,
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