Extracurricular laboratory: Synthetic route of 2-(2-(2-Bromoethoxy)ethoxy)ethanol

According to the analysis of related databases, 57641-67-5, the application of this compound in the production field has become more and more popular.

Electric Literature of 57641-67-5, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 57641-67-5, name is 2-(2-(2-Bromoethoxy)ethoxy)ethanol. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: Potassium carbonate (916 mg, 6.6 mmol) was added to the solution of imidazole (375 mg, 5.5 mmol) and oligoethylene glycolic bromide (4a-e, 5.5 mmol) in acetone (30 mL) at 25 C. The residue was dissolved in water (50 mL) and extracted from the aqueous phase with EtOAc (50 mL¡Á3). The organic layer was dried (sodium sulfate) and evaporated under reduced pressure. The residue was purified by flash column chromatography (10% MeOH/CH2Cl2) to afford the corresponding oligoethylene glycolic imidazole (5a-e).

According to the analysis of related databases, 57641-67-5, the application of this compound in the production field has become more and more popular.

Reference:
Article; Jadhav, Vinod H.; Kim, Ju-Young; Chi, Dae Yoon; Lee, Sungyul; Kim, Dong Wook; Tetrahedron; vol. 70; 2; (2014); p. 533 – 542;,
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