Application of 100751-63-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 100751-63-1, name is 6-Bromo-2-naphthylmethanol, molecular formula is C11H9BrO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Under a nitrogen atmosphere, the compound obtained in the second step to the reactor (T-3) was charged (23.6 g, 99.6 mmol) and methylene chloride (250ml). The solution was cooled to 0 , and Dess-Martin periodinane; was added in portions (DMP 42.2g, 99.6mmol) to 3 times. The mixture was stirred for a further 2 hours while returning to room temperature. The reaction mixture was poured into saturated aqueous sodium bicarbonate solution (300 ml), then was subjected to filtration, the filtrate was extracted with ethyl acetate. The organic layers were washed with water, aqueous sodium sulfite, and washed sequentially with water and saturated brine, and dried over anhydrous magnesium sulfate. The solution was concentrated under reduced pressure, the residue was purified by silica gel chromatography (eluent: toluene) to give the compound (T-4) (19.05g, 81.0mmol; 81%) was obtained.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 100751-63-1, 6-Bromo-2-naphthylmethanol.
Reference:
Patent; JNC CORPORATION; JNC PETROCHEMICAL CORPORATION; GOTO, MAYUMI; TANAKA, HIROYUKI; (104 pag.)JP2016/37458; (2016); A;,
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