Electric Literature of 100751-63-1, Adding some certain compound to certain chemical reactions, such as: 100751-63-1, name is 6-Bromo-2-naphthylmethanol,molecular formula is C11H9BrO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 100751-63-1.
To a solution of (6-bromonaphtbalen-2-yl)methanol (0.7 g, 2.97 mmol) in dichloromethane (20mL) was added TBSCI (667 mg, 4.45 mmol) and imidazole (302 mg, 4.45 mmol). After theaddition, the reaction mixture was stirred at 25 C for 1 h. The reaction was then quenched by addition of saturated aqueous NI-l4Cl (20 mE) and extracted with ethyl acetate (3 x 30 mL). The combined organic layers were dried over Na2SO4 and concentrated under reduced pressure. The residue was purified by silica-gel chromatography (petroleum ether: ethyl acetate = 30: 1) togive the title compound (0.8 g, 77 % yield) as a colorless oil.
According to the analysis of related databases, 100751-63-1, the application of this compound in the production field has become more and more popular.
Reference:
Patent; GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.; ALBRECHT, Brian, K.; COTE, Alexandre; GEHLING, Victor; HSIAO-WEI TSUI, Vickie; KIEFER, James, Richard, Jr.; LIANG, Jun; MAGNUSON, Steven; NASVESCHUK, Christopher, G.; PASTOR, Richard; ROMERO, F. Anthony; TAYLOR, Alexander, M.; ZHANG, Birong; (287 pag.)WO2016/112284; (2016); A1;,
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