Application of 1208434-90-5 , The common heterocyclic compound, 1208434-90-5, name is (2,6-Difluoro-3,5-dimethoxyphenyl)methanol, molecular formula is C9H10F2O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
To a solution of (2,6-difluoro-3,5-dimethoxyphenyl)methanol (1.5g, 7.38mmol) in diethyl ether (20mL), and pyridine (0.029g, 0.3mmol), PBr3 (0.69mL, 7.38mmol) was added slowly over a period of 10 min. Reaction mass was stirred at 35 C for 3hr. Reaction mass was quenched with ice cold water and extracted with diethyl ether (3x25mL). The organic phase was washed with brine, dried over Na2S04, filtered and concentrated under vacuum. The residue was purified by silica gel column chromatography to afford the title compound (1.68g, yield: 85.2%). 1H-NMR (CDC13, 300MHz): 6.60 (t, 1H), 4.52 (s, 2H), 3.87 (s, 6H).
The synthetic route of 1208434-90-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; EISAI R & D MANAGEMENT CO., LTD.; REYNOLDS, Dominic; HAO, Ming-Hong; WANG, John; PRAJAPATI, Sundeep; SATOH, Takashi; SELVARAJ, Anand; (128 pag.)WO2016/164703; (2016); A1;,
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