With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.6153-05-5, name is (Z)-3-Methylpent-2-en-4-yn-1-ol, molecular formula is C6H8O, molecular weight is 96.13, as common compound, the synthetic route is as follows.Safety of (Z)-3-Methylpent-2-en-4-yn-1-ol
n-BuLi (4.2 mL, 10 mmol, 2.4 mol/L) was added dropwise to a solution of (Z)-3-methylpent-2-en-4-yn-1-ol (0.48 g, 5 mmol) in THF (10 mL) at ?78 ¡ãC under a N2 atmosphere, andthen the mixture was stirred for 1 h at ?78 ¡ãC. A solution of 4e (1.01 g, 5 mmol) in THF (5 mL) wasadded slowly, the mixture was stirred for 0.5 h at ?78 ¡ãC, and then it was warmed to room temperatureand stirred for 2 h. The reaction was quenched with saturated aqueous NH4Cl solution (10 mL) andextracted with EtOAc (3 ¡Á 30 mL). The combined organics were washed with brine (2 ¡Á 20 mL), driedover anhydrous Na2SO4 and concentrated. The residue was purified by silica gel columnchromatography (petroleum ether/EtOAc, 1:1) to afford 6i (1.40 g, 94percent) as a yellow oil.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,6153-05-5, (Z)-3-Methylpent-2-en-4-yn-1-ol, and friends who are interested can also refer to it.
Reference:
Article; Han, Xiaoqiang; Wan, Chuan; Yang, Dongyan; Yuan, Xiaoyong; Du, Shijie; Xiao, Yumei; Qin, Zhaohai; Molecules; vol. 18; 9; (2013); p. 10776 – 10788;,
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