Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 32328-03-3, name is Diethyl 3-hydroxyglutarate. A new synthetic method of this compound is introduced below., Recommanded Product: 32328-03-3
1. Synthesis of 1,3,5-Pentanetriol (II)Diethyl 3-hydroxyglutarate (I, 1.0 g, 4.9 mmol) in anhydrous THF (10 mL) was added dropwise to a suspension of LiAlH4 in anhydrous THF (110 mL) under nitrogen with a cold water bath. Upon addition, the bath was removed and the suspension was stirred at room temperature for 2 days. The resulting mixture was quenched by adding 13 mL of brine very slowly with an ice-water bath. A white suspension was resulted, and the mixture was stirred at room temperature overnight. The solid was filtered, and washed with THF. The filtrate and wash were combined, and solvent evaporated to give 0.70 g of pale oil. Column chromatography of the crude product (230-400 mesh SiO2, 100 mL, 0-12% methanol gradient in chloroform) afforded 0.54 g of II as colourless oil.
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Reference:
Patent; Tekmira Pharmaceuticals Corporation; Manoharan, Muthiah; Jayaraman, Muthusamy; Rajeev, Kallanthottathil G.; Eltepu, Laxman; Ansell, Steven; Chen, Jianxin; US9186325; (2015); B2;,
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