Electric Literature of 6642-34-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 6642-34-8, name is (6-Bromobenzo[d][1,3]dioxol-5-yl)methanol. This compound has unique chemical properties. The synthetic route is as follows.
General procedure: In an oven dried Schlenk tube, were added alcohol 1 (100.0mg, 0.31-0.53mmol), ethyl acrylate [155.1-265.3mg, (i.e., 1.55-2.65 mmol)], and Cs2CO3 [303.0-518.0mg, (i.e., 0.93-1.59mmol)] followed by the addition of toluene (2mL) at rt under nitrogen atmosphere. The resulted reaction mixture was stirred at 50C in an oil bath for 48h. After the completion of Michael addition (monitored by TLC) and to the cooled reaction mixture at rt, were added Pd(OAc)2 (6.9-11.9mg, 10mol%) and PPh3 (16.3-27.8mg, 20mol%) under nitrogen atmosphere. The reaction mixture was then heated at 80C in an oil bath for 24h. Once after formation intermolecular Heck coupling product, (monitored by TLC) and then to the cooled reaction mixture at rt, was added DMF (3mL) and heated to 120C, in an oil bath for 12h (monitored by TLC). The reaction mixture at rt was quenched by the addition of aqueous NH4Cl and extracted with DCM (3¡Á15mL). The organic layers were washed with saturated NaCl solution, dried (Na2SO4), and filtered. Evaporation of the solvent under reduced pressure and purification of the crude material by silica gel column chromatography (petroleum ether/ethyl acetate) furnished the lactenones 5 (40-48%).
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 6642-34-8, (6-Bromobenzo[d][1,3]dioxol-5-yl)methanol.
Reference:
Article; Reddy, A. Gopi Krishna; Krishna; Satyanarayana; Tetrahedron; vol. 69; 47; (2013); p. 10098 – 10107;,
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