According to the analysis of related databases, 616-29-5, the application of this compound in the production field has become more and more popular.
616-29-5 , The common heterocyclic compound, 616-29-5, name is 1,3-Diaminopropan-2-ol, molecular formula is C3H10N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Example 13 delta-CS-BromophenvD-S-hvdroxy-delta-^-methoxyphenylVS^J^-tetrahydroimidazorLS- alpyrimidine-6(2H)-thione4-(3-Bromophenyl)-4-(4-methoxyphenyl)-l,3-thiazolidine-2,5-dithione (82 mg, 0.20 mmol), l,3-diaminopropan-2-ol (54 mg, 0.60 mmol) and triethylamine (139 muL, 1 mmol), was heated to 70 C in ethanol (2 mL) for 1 h. The mixture was concentrated in vacuo and the residue was diluted with ethyl acetate and washed with aqueous sodium carbonate, brine, dried over sodium sulfate and concentrated in vacuo. The crude product was purified by column chromatography using an eluent with ethyl acetate in heptane (0-100 %) to give 83 mg (96 % yield): MS (AP) m/z 433 [M+l]+.
According to the analysis of related databases, 616-29-5, the application of this compound in the production field has become more and more popular.
Reference:
Patent; ASTRAZENECA AB; ASTEX THERAPEUTICS LTD; WO2007/145571; (2007); A1;,
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