106-28-5, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 106-28-5 as follows.
Step 4: A 3-N 100 mL flask was charged with PCl3 (2.8 mL, 31.6 mmol) and dry DMF (32 mL) then stirred at RT for 1 h. In a separate 50 mL flask, farnesol (Ex-1B-5) (10.0 g, 45.2 mmol) and DMF (10 mL) was charged. The PCl3/DMF solution was then transferred to the farnesol, solution and the resulting dark orange solution was stirred for 1 h. The reaction was quenched by addition of solid NaHCO3 (2.5 g, 63.2 mmol). The solvent was removed by high vacuum rotary evaporation to yield an oily orange residue. To the residue was added MTBE (40 mL) and water (40 mL). The aqueous phase was washed with MTBE (3¡Á20 mL). The MTBE layers were combined, washed with brine (2¡Á20 mL), dried over MgSO4, filtered and finally concentrated by rotary evaporation to yield 1-chloro-3,7,11-trimethyl-dodeca-2,6,10-triene (Ex-1B-6) as a yellow oil (9.89 g, 92%). 1H NMR (400 MHz, CDCl3) delta (ppm): 5.47 (broad-t, J=8.3 Hz, 1 H), 5.15-5.07 (m, 2 H), 4.12 (d, J=8.1 Hz, 2 H), 2.18-1.95 (m, 8 H), 1.75 (s, 3 H), 1.70 (s, 3 H), 1.62 (s, 6 H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,106-28-5, its application will become more common.
Reference:
Patent; Miller, Guy M.; Hecht, Sidney M.; US2006/281809; (2006); A1;,
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