In 2018,Chemical Communications (Cambridge, United Kingdom) included an article by Miller, Miles A.; Kim, Eunha; Cuccarese, Michael F.; Plotkin, Alec L.; Prytyskach, Mark; Kohler, Rainer H.; Pittet, Mikael J.; Weissleder, Ralph. SDS of cas: 27489-62-9. The article was titled 《Near infrared imaging of Mer tyrosine kinase (MERTK) using MERi-SiR reveals tumor associated macrophage uptake in metastatic disease》. The information in the text is summarized as follows:
The receptor tyrosine kinase Mer (MERTK) is a promising drug target in cancer, where it can influence the metastasis-promoting signaling of both tumor cells and immune cells alike; however, no small mol. probes currently exist to selectively image Mer. In this work, we design and synthesize a selective near-IR fluorescent mol. probe of Mer (MERi-SiR). Confocal microscopy of metastases in mice reveals predominant probe accumulation in Mer-expressing tumor-associated macrophages. The experimental part of the paper was very detailed, including the reaction process of trans-4-Aminocyclohexanol(cas: 27489-62-9SDS of cas: 27489-62-9)
trans-4-Aminocyclohexanol(cas: 27489-62-9) belongs to anime. Acylation is one of the most important reactions of primary and secondary amines; a hydrogen atom is replaced by an acyl group (a group derived from an acid, such as RCOOH or RSO3H, by removal of ―OH, such as RC(=O)―, RS(O)2―, and so on). Reagents may be acid chlorides (RCOC1, RSO2C1), anhydrides ((RCO)2O), or even esters (RCOOR′); the products are amides of the corresponding acids.SDS of cas: 27489-62-9
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