Analysis of the essential oil of magnolia and its effect on antioxidant enzyme activity, sCD40L and phosphorylate-activate Akt protein levels in gastric cancer mice was written by Li, Rui;Chen, Wei-chang;Wang, Wei-peng;Tian, Wen-yan;Zhang, Xue-guang. And the article was included in Medicinal Chemistry Research in 2010.Quality Control of rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate This article mentions the following:
The chem. composition of essential oil from magnolia collected in Suzhou city, China, was studied using gas chromatog.-mass spectroscopy. Fifty-four volatile compounds were identified in the essential oil, with eucalyptol (21.55%), β-Pinene(11.07%), D-Limonene (8.93%), 1R-α-Pinene (7.86%), Bicyclo[2.2.1]heptan-2-one, 1,7,7-trimethyl-, (1R)-(6.46%), Cyclohexene, 4-methylene-1-(1-methylethyl)- (5.30%), 1,4-Cyclohexadiene, 1-methyl-4-(1-methylethyl)- (5.10%), camphene (4.72%), being the major chem. constituents. In an in vivo approach, the protective effect of the essential oil against oxidative stress in gastric cancer (GC) mice was also investigated in terms of superoxide dismutase, CAT, and glutathione peroxidase activities. Our results indicate that the essential oil has an effective capability to enhance serum antioxidant enzyme activities and sCD40L, and decrease phosphorylate-activate Akt protein levels in a dose-dependent manner in gastric cancer mice. Overall, essential oil from magnolia appears to be an effective antioxidant and is quite suitable for further biol. evaluation. In the experiment, the researchers used many compounds, for example, rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate (cas: 2451-01-6Quality Control of rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate).
rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate (cas: 2451-01-6) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Quality Control of rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate
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