Efficient Ru(II)-catalyzed asymmetric hydrogenation of simple ketones with C2-symmetric planar chiral metallocenyl phosphinooxazoline ligands was written by Guo, Hui;Liu, Delong;Butt, Nicholas A.;Liu, Yangang;Zhang, Wanbin. And the article was included in Tetrahedron in 2012.Formula: C8H9ClO This article mentions the following:
C2-sym. metallocenyl planar phosphinooxazoline ligands have been applied in the Ru(II)-catalyzed asym. hydrogenation of simple ketones. This type of ligand enjoys the advantages of dual reaction sites as well as larger steric hindrance than their corresponding C1-sym. counterparts. As a result, almost quant. conversions and excellent enantioselectivities were obtained for a series of simple ketones. Under the optimal reaction conditions, up to 99.7% ee was obtained in many cases. It was also confirmed that hydrogen rather than the reaction solvent i-PrOH is at work in the hydrogenation procedure. In the experiment, the researchers used many compounds, for example, (R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9Formula: C8H9ClO).
(R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Formula: C8H9ClO
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts