Synthesis and antiproliferative properties of N3/8-disubstituted 3,8-diazabicyclo[3.2.1]octane analogues of 3,8-bis[2-(3,4,5-trimethoxyphenyl)pyridin-4-yl]methyl-piperazine was written by Filosa, Rosanna;Peduto, Antonella;De Caprariis, Paolo;Saturnino, Carmela;Festa, Michela;Petrella, Antonello;Pau, Amedeo;Pinna, Gerard Aime;La Colla, Paolo;Busonera, Bernardetta;Loddo, Roberta. And the article was included in European Journal of Medicinal Chemistry in 2007.Electric Literature of C6H6BrNO This article mentions the following:
A series of novel N3/8-disubstituted-3,8-diazabicyclo[3.2.1]octanes in order to improve the in vitro activity of the prototype 3,8-bis[2-(3,4,5-trimethoxyphenyl)pyridyl-4-yl]methylpiperazine were synthesized and evaluated by assays of growth inhibition against several tumor cell lines. Several compounds demonstrated not only growth-inhibitory activities against leukemia cancer cells, but also fairly good activities against the growth of certain solid tumors. Among them, I is the most potent one with IC50 values in the low micromolar range. Moreover, I has been selected for in vitro testing on MCF-7 cell to evaluate the mode of action of this lead compound In the experiment, the researchers used many compounds, for example, 2-Bromopyridine-4-methanol (cas: 118289-16-0Electric Literature of C6H6BrNO).
2-Bromopyridine-4-methanol (cas: 118289-16-0) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Electric Literature of C6H6BrNO
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts