2′,6′-Dihydroxy-4′-methylacetophenone (cas: 1634-34-0) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Synthetic Route of C9H10O3
Na+-Glucose Cotransporter (SGLT) Inhibitors as Antidiabetic Agents. 4. Synthesis and Pharmacological Properties of 4′-Dehydroxyphlorizin Derivatives Substituted on the B Ring was written by Tsujihara, Kenji;Hongu, Mitsuya;Saito, Kunio;Kawanishi, Hiroyuki;Kuriyama, Kayoko;Matsumoto, Mamoru;Oku, Akira;Ueta, Kiichiro;Tsuda, Minoru;Saito, Akira. And the article was included in Journal of Medicinal Chemistry in 1999.Synthetic Route of C9H10O3 This article mentions the following:
In the authors’ studies of Na+-glucose cotransporter (SGLT) inhibitors as antidiabetic agents, a series of novel 4′-dehydroxyphlorizin derivatives substituted on the B ring was prepared and their effects on urinary glucose excretion were evaluated in rats. Introduction of only a small alkyl group at the 4′-position increased the activity, and 3-(benzo[b]furan-5-yl)-2′,6′-dihydroxy-4′-methylpropiophenone 2′-O-β-D-glucopyranoside I (R = H) showed the most potent effect. To overcome hydrolysis by β-glucosidase in the digestive tract, the OH groups on the glucose moiety of I (R = H) were modified. Three prodrugs were more potent than the parent compound by oral administration, and finally 3-(benzo[b]furan-5-yl)-2′,6′-dihydroxy-4′-methylpropiophenone 2′-O-(6-O-methoxycarbonyl-β-D-glucopyranoside) I (R = CO2Me) was selected as a new promising candidate. This compound was metabolized mainly by liver esterase to the active form, I (R = H) which was about 10 times more potent in inhibiting SGLT. In oral glucose tolerance test in db/db mice, I (R = CO2Me) dose-dependently suppressed the elevation of glucose levels. Single administration reduced hyperglycemia concurrently with increase of glucose excretion into urine in diabetic KK-Ay mice. Furthermore, I (R = CO2Me) suppressed the elevation of blood glucose levels but did not lower it below the normal level even in fasted conditions in KK-Ay mice. Addnl., long-term treatment dose-dependently reduced hyperglycemia and HbA1c in KK-Ay mice. These pharmacol. data strongly suggest that I (R = CO2Me) has a therapeutic potential in the treatment of NIDDM. In the experiment, the researchers used many compounds, for example, 2′,6′-Dihydroxy-4′-methylacetophenone (cas: 1634-34-0Synthetic Route of C9H10O3).
2′,6′-Dihydroxy-4′-methylacetophenone (cas: 1634-34-0) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Synthetic Route of C9H10O3
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts