Organosuperbase-Catalyzed 1,1-Diboration of Alkynes was written by Doan, Son H.;Ton, Nhan N. H.;Mai, Binh Khanh;Nguyen, Thanh Vinh. And the article was included in ACS Catalysis in 2022.Related Products of 1214264-88-6 This article mentions the following:
1,1-Diboryl alkenes are versatile building blocks in organic synthesis and medicinal chem. However, there have been only a small number of established methods to prepare this class of compounds, and most of them used transition-metal catalysts, which are undesirable in the preparation of biol. relevant compounds Herein, authors report an unprecedented application of P1–tBu phosphazene as a superbasic organocatalyst to promote 1,1-diboration reactions of unactivated aromatic and electron-deficient terminal alkynes. The dual Bronsted and Lewis basicity of this phosphazene enables the activation of reaction substrates and allows for high regio- and stereoselectivity to be obtained. A combination of thorough exptl. and computational studies suggests interesting mechanistic insights for these phosphazene-catalyzed diboration reactions, which are also discussed in detail. In the experiment, the researchers used many compounds, for example, 2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydro-1H-naphtho[1,8-de][1,3,2]diazaborinine (cas: 1214264-88-6Related Products of 1214264-88-6).
2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydro-1H-naphtho[1,8-de][1,3,2]diazaborinine (cas: 1214264-88-6) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Related Products of 1214264-88-6
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts