Facile synthesis of axially chiral styrene-type carboxylic acids via palladium-catalyzed asymmetric C-H activation was written by Yang, Chi;Wu, Tian-Rui;Li, Yan;Wu, Bing-Bing;Jin, Ruo-Xing;Hu, Duo-Duo;Li, Yuan-Bo;Bian, Kang-Jie;Wang, Xi-Sheng. And the article was included in Chemical Science in 2021.Reference of 68716-49-4 This article mentions the following:
A novel method by a one-step introduction of axial chirality and sterically hindered group were developed for facile synthesis of axially chiral styrene-type carboxylic acids. With the palladium-catalyzed C-H arylation and olefination of readily available cinnamic acid established, this transformation demonstrated excellent yield, excellent stereocontrol (up to 99% yield and 99% ee), and broad substrate scope under mild conditions. The axially chiral styrene-type carboxylic acids produced were successfully applied to Cp*Co(III)-catalyzed asym. C-H activation reactions, indicating their potential as chiral ligands or catalysts in asym. synthesis. In the experiment, the researchers used many compounds, for example, 2-(4-Bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 68716-49-4Reference of 68716-49-4).
2-(4-Bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 68716-49-4) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Reference of 68716-49-4
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts