One-Pot Synthesis of B-Ring Ortho-Hydroxylated Sappanin-Type Homoisoflavonoids was written by Mrug, Galyna P.;Myshko, Nataliia V.;Bondarenko, Svitlana P.;Sviripa, Vitaliy M.;Frasinyuk, Mykhaylo S.. And the article was included in Journal of Organic Chemistry in 2019.Synthetic Route of C7H6O3 This article mentions the following:
A reliable method for the synthesis of B-ring hydroxylated homoisoflavonoids (e.g. I) and 3-hetarylmethyl chromones has been developed. The method involves an initial oxa-Diels-Alder reaction of ortho-quinone methides generated from aryl/hetaryl-substituted ortho-(N,N-dimethylaminomethyl)phenols with (2E)-3-(N,N-dimethylamino)-1-(2-hydroxyphenyl)prop-2-en-1-ones and the subsequent cascade of reactions. This synthetic strategy avoids conventional multistep protocols and does not require the protection of hydroxyl groups, thus allowing the facile synthesis of a library of various aromatic and heterocyclic analogs of naturally occurring homoisoflavonoids. In the experiment, the researchers used many compounds, for example, Benzo[d][1,3]dioxol-4-ol (cas: 69393-72-2Synthetic Route of C7H6O3).
Benzo[d][1,3]dioxol-4-ol (cas: 69393-72-2) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Synthetic Route of C7H6O3
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts