Cobalt-catalysed CH-alkylation of indoles with alcohols by borrowing hydrogen methodology was written by Zhou, Bei;Ma, Zhuang;Alenad, Asma M.;Kreyenschulte, Carsten;Bartling, Stephan;Beller, Matthias;Jagadeesh, Rajenahally V.. And the article was included in Green Chemistry in 2022.Computed Properties of C7H9NO This article mentions the following:
A general heterogeneous cobalt-catalyzed CH-alkylation of indoles with alcs. was reported. Utilizing this straightforward borrowing hydrogen methodol., a series of substituted and functionalized indoles were easily coupled with benzylic, heterocyclic, and aliphatic alcs. including methanol to prepare >65 substituted indoles in good to excellent yields. The resulting products represented an interesting class of heterocyclic compounds widely used in organic synthesis and medicinal chem. Key for this synthesis was the use of specific cobalt-nanoparticles supported on N-doped carbon, which were conveniently prepared by the pyrolysis of a templated material generated in-situ by mixing cobalt-nitrate, zinc-nitrate, 2,6-diaminopyridine, and colloidal silica, and subsequent removal of silica. In the experiment, the researchers used many compounds, for example, 6-Methyl-2-pyridinemethanol (cas: 1122-71-0Computed Properties of C7H9NO).
6-Methyl-2-pyridinemethanol (cas: 1122-71-0) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Computed Properties of C7H9NO
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts