Selective Difunctionalization of Unactivated Aliphatic Alkenes Enabled by a Metal-Metallaaromatic Catalytic System was written by Cui, Fei-Hu;Hua, Yuhui;Lin, Yu-Mei;Fei, Jiawei;Gao, Le-Han;Zhao, Xiaodan;Xia, Haiping. And the article was included in Journal of the American Chemical Society in 2022.Quality Control of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol This article mentions the following:
The design of organometallic catalysts is crucial in the development of catalytic reactions. Herein, the authors describe a heterometallic [Os-Cu] complex with the characteristics of bimetallics, metallaaroms. and pincer complexes. This complex serves as a highly effective catalyst for selective amino- and oxyselenation of unactivated alkenes. More than 80 examples including challenging substrates of unsym. aliphatic alkenes and amine-based nucleophiles in such reactions are provided. These reactions produce 1,2-difunctionalized products with good yields and high levels of chemo-, regio- and stereoselectivity. The study revealed that (i) the usually inert Os center activates the N- or O-centered nucleophiles, (ii) the Cu-Os bonding and its cooperative effects play essential roles in control the selectivity by bringing the reaction components into close proximity, and (iii) the metallaarom. moiety helps to stabilize the intermediate. These findings provide a versatile platform for catalyst design based on metal-metallaarom. cooperative effects that were not attained previously with bimetallic complexes. In the experiment, the researchers used many compounds, for example, (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5Quality Control of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol).
(1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Quality Control of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts