Photolithographic patterning of 3D-formed polycarbonate films for targeted cell guiding was written by Hirschbiel, Astrid F.;Geyer, Simone;Yameen, Basit;Welle, Alexander;Nikolov, Pavel;Giselbrecht, Stefan;Scholpp, Steffen;Delaittre, Guillaume;Barner-Kowollik, Christopher. And the article was included in Advanced Materials (Weinheim, Germany) in 2015.Application In Synthesis of 3-(Hydroxymethyl)-4-nitrophenol This article mentions the following:
The authors employ a combination of photopatterning-via o-nitrobenzyl-mediated cleavage – and reversible-deactivation radical polymerization to achieve micropatterns of an oligo(ethylene glycol)(OEG) derivative and carboxylic acid moieties. Further, the authors evidenced that specific areas of the polymeric substrate can be opened for biol. impact, including strongly fouling sera such as fetal calf serum or fluorescent green protein. The introduced methodol. is to date the only avenue for cell guiding on a thin, thermoformable polycarbonate substrate making use of a simple photochem. approach. This work paves the way for a patterned surface functionalization of thermoformed microstructures which could serve as a base for applications ranging from simple patterned cell culture systems to advanced tissue cultures systems in 3D. In the experiment, the researchers used many compounds, for example, 3-(Hydroxymethyl)-4-nitrophenol (cas: 60463-12-9Application In Synthesis of 3-(Hydroxymethyl)-4-nitrophenol).
3-(Hydroxymethyl)-4-nitrophenol (cas: 60463-12-9) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Application In Synthesis of 3-(Hydroxymethyl)-4-nitrophenol
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts